Already tried using App-V 5.0 SP2 HF5 on Windows 10 Technical Preview or are you just before trying it? If yes, make sure you have at least installed Build 9860. There is a known issue with junctions. App-V 5.0 uses junctions, i.e. in “C:\ProgramData\Microsoft\AppV\Client\Integration”. You will get an error message when launch an App-V package thru the shortcut in the start menu because the file that is part of a junction folder cannot be found.
Other than that, App-V 5.0 SP2 HF5 worked perfectly on Windows 10, I haven’t experienced any issues so far with my packages….